Removal of Internally Deposited Transuranium Elements by Zn-DTPA
- 1 June 1972
- journal article
- research article
- Published by Wolters Kluwer Health in Health Physics
- Vol. 22 (6) , 779-783
- https://doi.org/10.1097/00004032-197206000-00037
Abstract
The comparative effectiveness of Ca-DTPA and Zn-DTPA in removing internally deposited 239Pu, 241Am and 242Cm was tested in the rat. The radionuclides were administered in a citrate solution and treatment with three chelate injections (1 mmol/kg−1d−1) was begun 6 days later. No essential differences were observed between the two chelates tested. The data indicate that the removal of the isotopes from the liver cannot be a suitable criterion far the effectiveness of treatment in other soft tissue organs. The liver isotope content was reduced to 10 % of the controls, whereas the content of other organs, including bone, was never reduced to less than 40 % of the control. In liver and lung, the response to treatment was different for 241Am and 242Cm as compared to 239Pu. There was no such difference as far as other organs are concerned.Keywords
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