Faculty Opinions recommendation of Timing of low tidal volume ventilation and intensive care unit mortality in acute respiratory distress syndrome. A prospective cohort study.

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Abstract
Patients suffering from acute respiratory distress syndrome (ARDS) rarely die from respiratory failure but rather from the underlying cause during the early period and from pneumonia or sepsis with consecutive multiple organ system failure in the late period. Low tidal volume ventilation improves survival and other clinical outcome parameters by reducing alveolar over-distention. Interestingly, this prospective cohort study demonstrated that even by raising the tidal volume from 6ml/kg predicted body weight to 7ml/kg predicted body weight, the intensive care unit mortality increased by as much as 23%. This Recommendation is of an article referenced in an F1000 Faculty Review also written by Klaus Ulrich Klein.

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