Nasal Administration: A Tool for Tomorrow's Systemic Administration of Drugs
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 19 (1-2) , 101-122
- https://doi.org/10.3109/03639049309038763
Abstract
By its anatomy and physiology, due to the great amount of air treated there, the nasal route represents a very interesting possibility for the administration of products degraded in the gastro-intestinal tract or inhibited by the first hepatic pass. The nasal dosage forms most studied are bioadhesive hydrogels and microspheres, especially for the systemic administration of peptides.Keywords
This publication has 35 references indexed in Scilit:
- Peptide and protein drugs: II. Non-parenteral routes of deliveryInternational Journal of Pharmaceutics, 1991
- Hydrolysis of Peptides in the Nasal Cavity of HumansJournal of Pharmaceutical Sciences, 1990
- Effects of Absorption Enhancers on Human Nasal Tissue Ciliary Movement in VitroPharmaceutical Research, 1990
- The Molecular Weight Dependence of Nasal Absorption: The Effect of Absorption EnhancersPharmaceutical Research, 1990
- Absorption of Polyethylene Glycols 600 Through 2000: The Molecular Weight Dependence of Gastrointestinal and Nasal AbsorptionPharmaceutical Research, 1990
- Nasal delivery of progestational steroids in ovariectomized rabbits. II. Effect of penetrant hydrophilicityInternational Journal of Pharmaceutics, 1989
- Influence of molecular weight and charge on nasal absorption of dextran and DEAE-dextran in rabbitsInternational Journal of Pharmaceutics, 1989
- Analysis of Structural Requirements for the Absorption of Drugs and Macromolecules from the Nasal CavityJournal of Pharmaceutical Sciences, 1987
- The effect of molecular size on the nasal absorption of water-soluble compounds in the albino ratJournal of Pharmacy and Pharmacology, 1987
- Enkephalin hydrolysis in homogenates of various absorptive mucosae of the albino rabbit: Similarities in rates and involvement of aminopeptidasesLife Sciences, 1986