Inhibiting angiotensin receptors in the brain: possible therapeutic implications

Publisher Website
Google Scholar
Abstract
Arterial hypertension is closely correlated with the occurrence of stroke and also with the loss of cognitive function and dementia. The results of several trials, including Syst-Eur, PROGRESS, and the preliminary findings from SCOPE open the way to the possible prevention of dementia by antihypertensive treatment. In this respect, candesartan seems to be a promising drug as it has been shown to have neuroprotective effects in animal models of cerebral ischaemia and can prevent non-fatal strokes in elderly subjects with arterial hypertension.