Effect of sucrose polyester on fecal steroid excretion by 24 normal men

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Abstract
The effect of the nonabsorbable fat-like substance, sucrose polyester (SPE), on neutral steroid excretion was determined in 24 healthy men. Initially the subjects received for 10 days a basal diet that was high (800 mg/day) or low (300 mg/day) in cholesterol or for 21 days a basal diet containing β-sitosterol to its characteristic products in the same proportion as was cholesterol. The addition of SPE to the diet caused a lesser amount of the sterols to be modified by the bacteria. This could be measured more readily in the converter population. There, each gram of SPE that was ingested resulted in 1.1% decrease in conversion for those who received liquid SPE and a 0.6% decrease for those who received the SPE-hydrogenated palm oil mix. The decrease in conversion is a probable consequence of the sterols being dissolved in the oil phase of SPE in the lumen of the intestinal tract and hence unavailable to the bacteria.