Evidence for posttranslational control of fetal hemoglobin synthesis
- 1 September 1988
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 29 (1) , 58-59
- https://doi.org/10.1002/ajh.2830290116
Abstract
Subunit competition experiments were conducted by recombining various amounts of α-subunits with an equimolar mixture of γ-and βA-subunits. The results showed that γ-subunits combine with α-subunits less readily than β-subunits. Thus, in the presence of α-chain deficiency (α-thalassemia) the formation of HbA is preferred over HbF, resulting in a decrease in the level of the latter.Keywords
This publication has 9 references indexed in Scilit:
- Influence of γ-chain amino-terminal acetylation on subunit assembly of human fetal hemoglobinBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1987
- Subunit assembly of hemoglobin: an important determinant of hematologic phenotypeBlood, 1987
- Modulation of Fetal Hemoglobin Synthesis by Iron DeficiencyNew England Journal of Medicine, 1985
- HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC SEPARATION OF GLYCOSYLATED AND ACETYLATED MINOR HEMOGLOBINS IN NEWBORN-INFANTS AND IN PATIENTS WITH SICKLE-CELL DISEASE1984
- Competition of normal β chains and sickle haemoglobin β chains for α chains as a post-translational control mechanismNature, 1978
- VARIABILITY IN INTERACTION OF BETA-THALASSEMIA WITH ALPHA-CHAIN VARIANTS HB G-PHILADELPHIA AND HB RAMPA1978
- Possible Relationship Between the Level of Hb Bart's (γ4) and the Relative Amount of Hb S or Hb C in Black Heterozygous NewbornHemoglobin, 1978
- Differences in Affinity of Variant β Chains for a Chains: A Possible Explanation for the Variation in the Percentages of β Chain Variants in HeterozygotesHemoglobin, 1977
- Separation of Human Hemoglobins by Deae-Cellulose Chromatography using Glycine-Kcn-Nacl DevelopersHemoglobin, 1976