Whole-body Autoradiography of Tumor-bearing Hamsters with a New Tumor Imaging Agent, Indium-111-labeled Porphyrin
- 1 July 1988
- journal article
- research article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 79 (7) , 880-884
- https://doi.org/10.1111/j.1349-7006.1988.tb00051.x
Abstract
We have synthesized a new tumor imaging agent, 111In-labeled porphyrin (111In-ATN-2). In order to image transplantable pancreatic carcinoma in Syrian golden hamsters, we investigated the biodistribution of 111In-ATN-2 72 hr after injecting the agent by means of whole-body autoradiography. The efficacy of the agent was compared with that of 67Ga citrate. The images with 111In-ATN-2 were found to be clearer than those with 67Ga citrate. Tumor-to-tissue radiodistribution ratios of the former were higher than those of the latter. Thus, 111In-ATN-2 seems to be more useful for tumor diagnosis.Keywords
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