The Lipolytic Activity of Low Concentrations of Insulin-Like Growth Factors in Ovine Adipose Tissue*
- 1 June 1988
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 122 (6) , 2554-2557
- https://doi.org/10.1210/endo-122-6-2554
Abstract
Insulin-like growth factor I (IGF-I) at concentrations of 40 ng/ml is lipogenic in ovine adipose tissue slices in vitro. Neither human IGF-II (hIGF-II) or rat IGF-II (rIGF-II) [multiplication-stimulating activity (MSA)] is lipogenic at similar concentrations. However, when present at lower concentrations recombinant human IGF-I (rhIGF-I) (400 pg/ml), hIGF-II (0.4 pg/ml), and MSA (40 pg/ml) were lipolytic. As IGF-II appeared more potent than IGF-I in promoting lipolysis, this effect may be mediated via the type 2 IGF receptor. The lipolytic effect of GH may be partly due to the actions of IGFs released locally.This publication has 10 references indexed in Scilit:
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