The effect of stress and corticotrophin on the concentrations of vitamin C in blood and tissues of the rat

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Abstract
The effects of various procedures on the concentrations of ascorbate and of dehydroascorbate plus dioxogulonate in blood and various tissues of anaesthetized rats have been investigated. Laparotomy, hamorrhage and administration of corticotrophin increase the concentrations in blood. The rise can be seen when the adrenals are excluded from the circulation, the highest concentrations being in blood from the inferior vena cava above the diaphragm; the femoral arteriovenous difference becomes increasingly negative. The concen-trations of ascorbate in several tissues (liver, spleen and kidney) are significantly increased in corticotrophin-treated animals, and the accompanying fall in the liver content of dehydroascorbate plus dioxogulonate is consistent with diminished ascorbate catabolism. There is no support for the view that corticotrophin promotes the oxidation of ascorbate.

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