Effects of antiarrhythmic agents classified as class III group on ischaemia‐induced myocardial damage in canine hearts

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Abstract
1 The cardioprotective effects of antiarrhythmic agents classified as class III, amiodarone, sotalol and E-4031, were investigated in anaesthetized dogs. 2 The left anterior descending coronary artery was occluded for 2 h. 3 Heart mitochondria were prepared from both the ischaemic and non-ischaemic areas, and their function was estimated polarographically. 4 Activities of the lysosmal enzymes, N-acetyl-β-glucosaminidase and β-glucuronidase, were measured in each fraction. 5 Two hour occlusion induced ventricular arrhythmias, and amiodarone, sotalol and E-4031 greatly suppressed the development of arrhythmias. 6 Amiodarone, sotalol and E-4031 significantly protected mitochondria against ischaemia, and prevented ischaemia-induced leakage of lysosomal enzymes. 7 Antiarrhythmic agents classified as class III show cardioprotective effects, which might participate in their antiarrhythmic effect.