A New Tyrosine Kinase Inhibitor from the Marine Brown Alga Stypopodium zonale
- 13 May 1999
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 62 (6) , 927-930
- https://doi.org/10.1021/np990010h
Abstract
From the lipophilic extract of the marine brown alga Stypopodium zonale (Dictyotaceae) the new terpenoid compound stypoquinonic acid (1) together with the known compounds taondiol (2) and atomaric acid (3) were isolated. The structures of all isolates were determined from their spectroscopic data, including 1- and 2-dimensional NMR methods. The new compound, 1, and atomaric acid (3), showed inhibition of tyrosine kinase (p56lck).Keywords
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