Cyclophosphamide and Cortisone Acetate Inhibit Complement Biosynthesis by Guinea Pig Bronchoalveolar Macrophages
Open Access
- 1 September 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 123 (3) , 1318-1321
- https://doi.org/10.4049/jimmunol.123.3.1318
Abstract
To explore mechanisms of drug-induced alterations in local host defenses in the lung, the capacity of guinea pig alveolar macrophages to synthesize the second (C2) and fourth (C4) components of complement was studied following treatment with cyclophosphamide and cortisone acetate. Administration of either drug significantly inhibited biosynthesis of C2 and C4 within 1 day. After 1 week of treatment, local complement synthesis was inhibited approximately 80%, although serum levels of the corresponding proteins were normal.This publication has 3 references indexed in Scilit:
- Cell-free synthesis of the fourth component of guinea pig complement (C4): identification of a precursor of serum C4 (pro-C4).Proceedings of the National Academy of Sciences, 1977
- IMMUNOLOGICAL REACTIVITY OF LUNG .4. EFFECT OF CYCLOPHOSPHAMIDE ON ALVEOLAR MACROPHAGE CYTOTOXIC EFFECTOR FUNCTION1977
- Cyclophosphamide: Use in PracticeAnnals of Internal Medicine, 1974