Initial Change of Glycosaminoglycans in Systemic Scleroderma
- 1 January 1975
- journal article
- Published by S. Karger AG in Dermatology
- Vol. 150 (6) , 334-345
- https://doi.org/10.1159/000251454
Abstract
7 clinically uninvolved as well as 8 involved (6 moderately, 2 markedly) back or forearm skin specimens from 12 patients with systemic scleroderma were subjected to quantitative evaluation and to qualitative analysis of glycosaminoglycans (GAG) by one-dimensional and two-dimensional cellulose acetate electrophoresis. Skin specimens from the back, clinically uninvolved but histologically demonstrating the initial change, revealed increased amounts of hyaluronidase, chondroitinase-resistant GAG of varying electrophoretic mobilities, and one of them was chemically confirmed to be heparan sulfate variant, whereas involved skin specimens showed hardly this increase.Keywords
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