A Glycoprotein Specified by Spleen Focus-forming Virus in Three Cell Lines Varies in Molecular Size and Peptide Composition, but Retains both Xenotropic and Ecotropic MuLV Antigenicity

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Abstract
A glycoprotein with an .apprx. MW of 55,000 encoded by spleen focus-forming virus (SFFV), was detected with an antiserum against xenotropic murine leukemia virus (MuLV) in various cell lines infected with the Friend strain of SFFV, suggesting that the SFFV-specific RNA coding for gp55 is related to the xenotropic virus. The proteins from 3 cell lines [mouse and rat] differed from each other in molecular size and gave different peptide maps. The differences in the gp55 molecules depended on differences in the SFFV genome but not on differences in glycosylation or processing of the precursor polypeptides of gp55 in different cells. These results indicate virus strain specificity of SFFV in gp55 formation.