Brief Communication : In Vitro Evidence of Specific BeG-Induced Immunity to Malignant Melanoma in BALB/c Mice

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Abstract
Lymphocytes from BCG-treated BALB/c mice were cytotoxic to S91 melanoma target cells but not to mammary carcinoma, 3-methylcholanthrene-induced sarcoma, or fibroblast target cells from BALB/c mice. Serum from BCG-treated mice was similarly cytotoxic to S91 target cells, but to neither of the other 2 tumor target cell lines. Resistance to cytotoxicity was not a factor in the failure of BCG-immune sera and lymphocytes to destroy the carcinoma and sarcoma target cells, since these cells were destroyed by tumor-specific immune lymphocytes and sera. Our results paralleled those obtained from previous in vivo experiments and suggested a specific BCG-induced protection against S91 melanoma in BALB/c mice.

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