QUANTITATIVE URINARY COPROPORPHYRIN EXCRETION AND ITS RELATION TO EDATHAMIL CALCIUM DISODIUM ADMINISTRATION IN CHILDREN WITH ACUTE LEAD INTOXICATION 12
Open Access
- 1 October 1956
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 35 (10) , 1131-1138
- https://doi.org/10.1172/jci103367
Abstract
A positive exponential correlation was found in childhood lead poisoning between the urinary lead output during the first day following the parenteral administration of edathamil calcium disodium and the daily urinary coproporphyrin output just prior to the administration of this chelating agent. A similar correlation was found between the simultaneous daily urinary outputs of coproporphyrin and lead during drug administration. It was postulated that the urinary coproporphyrin output is related to that fraction of lead in the tissues which is available for chelation and urinary excretion under the influence of edathamil calcium disodium. The urinary coproporphyrin excretion may provide a sensitive biochemical index of "metabolically active" and presumably toxic lead in the soft tissues.Keywords
This publication has 14 references indexed in Scilit:
- The purification and properties of δ-aminolaevulic acid dehydraseBiochemical Journal, 1955
- A TECHNIQUE FOR QUANTITATIVE URINE COLLECTION IN THE METABOLIC STUDY OF INFANTS AND YOUNG CHILDRENPediatrics, 1955
- Porphyrin metabolism. III. Urinary and erythrocyte porphyrin in children with acute rheumatic fever.1955
- Normal human urinary porphyrinsBiochemical Journal, 1954
- THE METABOLISM OF C-14 LABELED ETHYLENEDIAMINETETRA-ACETIC ACID IN HUMAN BEINGS1954
- The fate of intravenously administered coproporphyrin III in normal and lead-treated rabbitsBiochemical Journal, 1952
- AN IMPROVED METHOD FOR THE DETERMINATION OF URINARY COPROPORPHYRIN AND AN EVALUATION OF FACTORS INFLUENCING THE ANALYSIS1951
- PORPHYRIN CHROMOGENS OR PRECURSORS IN URINE, BLOOD, BILE, AND FECES1951
- Role of porphyrins in occupational diseases; significance of coproporphyrinuria in lead workers.1950
- THE ANEMIA OF INFECTION. I. HYPOFERREMIA, HYPERCUPREMIA, AND ALTERATIONS IN PORPHYRIN METABOLISM IN PATIENTS 1Journal of Clinical Investigation, 1946