Conformational studies of phosphorus-containing ring systems of pharmacological and biochemical importance-derivatives of cyclophosphamide and cyclic nucleotides
- 19 December 1983
- journal article
- research article
- Published by Taylor & Francis in Phosphorus and Sulfur and the Related Elements
- Vol. 18 (1-3) , 389-392
- https://doi.org/10.1080/03086648308076047
Abstract
Results of a systematic study of the conformational features of the 1, 3, 2-oxazaphosphorinane ring system characteristic of the antitumor drug cyclophosphamide and its congeners are reported. Comparisons are made to the related 1, 3, 2-dioxaphosphorinane ring system of nucleoside cyclic 3′, 5′-monophosphates, e. g. cAMP and cTMP, and their neutral derivatives, I.Keywords
This publication has 2 references indexed in Scilit:
- Conformations of saturated six-membered ring phosphorus heterocycles. cis- and trans-2-oxo- and -2-thio-2-(dimethylamino)-5-tert-butyl-1,3,2 .lambda.5-oxazaphosphorinanes: molecules related to cyclophosphamideJournal of the American Chemical Society, 1982
- Twist conformation for the cis N,N-dimethylphosphoramidate of thymidine 3′,5′-cyclic phosphateTetrahedron Letters, 1980