High‐Dose Growth Hormone Treatment of Non‐Growth Hormone‐Deficient Children: Preliminary Results after 2 Years
- 1 March 1990
- journal article
- Published by Wiley in Acta Paediatrica
- Vol. 79 (s366) , 38-40
- https://doi.org/10.1111/j.1651-2227.1990.tb11596.x
Abstract
The growth response to high‐dose growth hormone (GH) therapy was investigated in 10 short, prepubertal, slowly‐growing children. Two years treatment with recombinant human GH at a dose of 0.3 IU/kg daily 7 days per week resulted in a mean height increase of 19.5 cm (range 17–23 cm). There was a slight but not significant acceleration of bone age maturation. The treatment also induced a sustained increase in insulin secretion without detectable changes in glucose tolerance.Keywords
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