Iron and bacterial virulence ? a brief overview
- 1 January 1991
- journal article
- review article
- Published by Springer Nature in BioMetals
- Vol. 4 (1) , 7-13
- https://doi.org/10.1007/bf01135551
Abstract
Iron is now recognized as playing a vital role in infection. Not only does its restricted availability in tissue fluids present microbial pathogens with the problem of acquiring sufficient for multiplication in vivo, but it also constitutes a major environmental signal which co-ordinately regulates the expression of a number of virulence and metabolic genes. Progress in understanding the strategies used by pathogens for acquiring iron in vivo, and their responses to iron restriction, is providing a fresh insight into microbial pathogenicity.Keywords
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