In vivo and in vitro Absorption of Amino Acids and Dipeptides in the Small Intestine of Uremic Rats

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Abstract
The small intestinal absorptive capacity in partially nephrectomized rats was studied in vitro and in vivo. Severe uremia reduced the in vivo uptake of glycine, L-methionine and L-lysine, while the dipeptides glycyl-L-valine, glycyl-L-leucine and glycyl-L-lysine were not similarly affected. The in vitro study using everted rings failed to show any changes in the absorption of amino acids, dipeptides and glucose in uremic rats. The results indicate that in uremia, as in other adverse conditions, the amino acid absorptive step is more severely damaged than that of the dipeptide.

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