ADRENALIN LACTACIDEMIA: PROPORTIONALITY WITH DOSE

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Abstract
Intraven. inj. of adrenalin at rates of 0.00025, 0.00050, 0.00100, 0.00200, 0.00400, 0.00700 and 0.01000 mg. per kg. per min. for 5 mins. affects the blood lactic acid level of chloralose anesthetized cats. The approximate minimal effective dose for blood lactic acid elevation is 0.00100 mg. per kg. per min. Maximum blood lactic acid values are never attained during the inj. period. With rates of inj. of 0.002 and 0.004 mg. per kg. per min., maximum is attained 10 mins. after inj. and is. followed by return toward but not to normal during the subsequent 20-min. interval; with rates of inj. of 0.007 and 0.010 mg. per kg. per min. blood lactic acid continues to increase throughout the entire 1/2 hr. following inj. Total blood lactic acid increase for the entire 35-min. exptl. period is rapid up to rate of inj. of 0.002 mg. per kg. per min. and thereafter increases less rapidly but steadily in direct proportion to dosage. There is a slight indication that the 2 lowest rates of inj., which were also usually depressor, effect a decrease in blood lactic acid conc. This suggestion of the possible significance of its concomitant vascular effects may also find application in explanation of the progressive increase of blood lactic acid and decrease of hyperglycemia (previous report) resulting from inj. at the 2 highest rates that were used.

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