PANCURONIUM IN MATERNAL AND FOETAL SURUM

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Abstract
Attempts to quantify minute amounts of pancuronium bromide in serum have been complicated by the presence of other anaesthetic drugs. A method of bioassay for determining absolute amounts of this relaxant in maternal in materal venous and cord blood is described. Data in a selected series of patients having pancuronium bromide for Caesarean section under general anaesthesia are presented, using three doses in the clinical range. Maternal venous levels of 0.2–2 μg/ml pancuronium were found. Assayable pancuronium was present in the cord samples of only 2 out of 19 patients. It is suggested that in those infant sera containing pancuroinum there was a maternal factor operating which predisposed to placental passage of the relaxant.

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