Febrile and hematologic responses of rhesus monkeys to bacterial endotoxin

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Abstract
Experimental and environmental conditions were found to markedly affect both base-line temperature and febrile response of rhesus monkeys to Escherichia coli or Salmonella typhosa endotoxins. Uncovered, restrained animals had inconsistent and sometimes hypothermic temperature responses. Restrained monkeys covered with a light blanket or monkeys free in cages responded with fever more regularly. There was no consistent relationship between the dose of endotoxin and the development of fever under any of the conditions studied, and doses as high as 12,500 [mu]g/kg of E. coli and 10,000 [mu]g /kg of S. typhosa endotoxin produced no mortality. Granulocytopenia followed by granulocytosis was noted, but thrombocytopenia did not develop. Possible reasons for the resistance of the rhesus monkey to the febrile and lethal effects of bacterial endotoxins are discussed.

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