Tissue Reactions to Organotin-Stabilized Polyvinyl Chloride (PVC) Catheters

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Abstract
There has been an increasing incidence of glottic inflammatory reactions. A search of the literature for a cause disclosed that leachable substances in polyvinyl chloride (PVC) could cause tissue injury. A study revealed that PVC slivers cut from some catheters intended for endotracheal use caused toxic reactions when implanted in rabbit muscle. Cell culture studies were corroborative. The toxic substance was identified as an organotin compound. The investigators concluded that plastic devices for use in human patients should not contain organotin stabilizers or any other leachable toxic agent, and that standards for plastic devices used in medical practice should be established.

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