Linkage‐disequilibrium of the senegal haplotype with the βs gene in the republic of guinea
- 1 December 1995
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 50 (4) , 301-303
- https://doi.org/10.1002/ajh.2830500415
Abstract
We have determined the β gene cluster haplotype in 40 chromosomes carrying the βs mutation from individuals of the major ethnic groups living in the Republic of Guinea. Thirty-one of these were either the typical (n = 29) or the atypical (n = 2) Senegal haplotype demonstrating that in this region of Atlantic West Africa, the sickle mutation is in linkage disequilibrium with this particular β-gene cluster haplotype. Two individuals carrying one chromosome bearing the Benin haplotype were of Malinke ethnic origin. This is in keeping with the hypothesis that the Senegal β-gene cluster haplotype is linked to the βs gene in Atlantic West Africa.Keywords
Funding Information
- NIH (HL 38664)
- European Community (TS3-CT93-0244/ DG 12HSMU)
This publication has 2 references indexed in Scilit:
- The evolution of two west African populationsJournal of Molecular Evolution, 1992
- The Senegal DNA haplotype is associated with the amelioration of anemia in African-American sickle cell anemia patientsBlood, 1991