Use of a long acting somatostatin analogue in controlling life threatening ileostomy diarrhoea.
- 20 October 1984
- Vol. 289 (6451) , 1027-1028
- https://doi.org/10.1136/bmj.289.6451.1027
Abstract
A woman presented with persistent ileostomy diarrhoea unresponsive to conventional drug treatment and necessitating parenteral nutrition. Output was four to six litres of watery fluid per 24 hours while she was receiving oral nutrition and two to three litres when she was starved. Treatment with a long acting analogue of somatostatin (50 micrograms subcutaneously every 12 hours) reduced the ileostomy output to 2.0-2.5 litres/24 hours with an oral diet and the effluent became semiformed. Parenteral fluids could be stopped. Somatostatin may have a role in the treatment of secretory diarrhoea, but prospective controlled trials are necessary.This publication has 2 references indexed in Scilit:
- Somatostatin Decreases Diarrhea in Patients with the Short-Bowel SyndromeJournal of Clinical Gastroenterology, 1982
- Effect of somatostatin on diarrhea and on small intestinal water and electrolyte transport in a patient with pancreatic choleraDigestive Diseases and Sciences, 1982