Triple Helix Binding of Oligodeoxyribonucleotides Containing 8-Oxo-2′-deoxyadenosine
- 1 February 1993
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 12 (2) , 237-243
- https://doi.org/10.1080/07328319308021209
Abstract
Formation of a triple helix between an oligodeoxyribonucleotide containing 8-oxo-2′-deoxyadenosine and a DNA duplex target was studied as a function of pH. Above pH 7.4, the triple helix with the 8-oxo-2′-deoxyadenosine was more stable than the complex with an analogous oligodeoxyribonucleotide containing deoxycytidine instead of 8-oxo-2′-deoxyadenosine.Keywords
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