Phthalic ester, an artifactual contaminant in diazomethane prepared from N‐methyl‐N‐nitroso‐p‐toluenesulfonamide for the derivatization of prostaglandins
- 1 November 1980
- Vol. 15 (11) , 968-971
- https://doi.org/10.1007/bf02534424
Abstract
During analyses of prostaglandin (PG) methoxime methyl trimethylsilyl (MO‐ME‐TMS) ether derivatives by gas chromatography, we consistently observed a contaminant peak which we identified as di‐2‐ethylhexyl phthalate (DEHP). The diazomethane prepared from N‐methyl‐N‐nitroso‐p‐toluenesulfonamide (MNTSA) using the Diazald kit was the major source of DEHP. Several other materials also were significant sources. The concentrations of DEHP in these materials were quantified by gas chromatography‐mass spectrometry.This publication has 7 references indexed in Scilit:
- The Biosynthesis and Metabolism of ProstaglandinsAnnual Review of Physiology, 1979
- The effects of trans trans methyl linoleate on the concentration of prostaglandins and their precursors in ratProstaglandins, 1979
- Glass capillary column gas chromatography of phtalate estersJournal of Chromatography A, 1979
- Separation of prostaglandins and thromboxanes by gas chromatography with glass capillary columnsAnalytical Chemistry, 1978
- Simple device for preparing ethereal diazomethane without resorting to codistillationAnalytical Chemistry, 1973
- Toxicity and health threats of phthalate esters: review of the literature.Environmental Health Perspectives, 1973
- Chemical ionization mass spectrometry of complex molecules. VIII. Esters of di- and tricarboxylic acidsAnalytical Chemistry, 1971