Role of the Brainstem in Blood Pressure Regulation in the Dog

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Abstract
Pressor and depressor areas in the brainstem of the dog were mapped using thyratron discharges delivered through implanted electrodes placed with a stereotoxic instrument. Continuous blood pressure tracings were made using an electromanometer. The location and the quality of the responses were similar to those previously defined for the cat. The vasomotor changes were blocked by methonium compounds and tetraethylammonium chloride but the pressor responses were more resistent to such action than the depressor or cardiac responses. Within limits the level of the blood pressure did not alter the responses to brainstem stimulation either quantitatively or qualitatively. Electro-corticograms revealed a concomitant but not constant activation pattern. Pressor responses and hypertensive levels persisted despite multiple brainstem lesions. The significance of these findings for homeostasis of the animal and hyperpiesia in man is discussed.

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