CORRELATION BETWEEN ESTROGEN SULFOTRANSFERASE LEVELS AND ESTROGEN-RECEPTOR STATUS IN HUMAN PRIMARY BREAST-CARCINOMA

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 39  (12) , 5124-5126
Abstract
Estrogen sulfotransferase (EC 2.8.2.4) activity and estrogen receptor levels were measured in 32 human primary breast cancer cytosol preparations. Two types of tumors were identified: type 1, in which estrogen sulfotransferase levels were low (< 40 pmol 17.beta.-estradiol 3-sulfate formed/mg protein per 2 h) and were independent of [35S]adenosine 3''-phosphate 5''-phosphosulfate production from [35S]sulfate and ATP; and type 2, in which estrogen sulfotransferase levels ranged from 50-200 pmol 17.beta.-estradiol 3-sulfate/mg protein per 2 h and were correlated with [35S]adenosine 3''-phosphate 5''-phosphosulfate formation (r [correlation coefficient] = 0.70; P < 0.005). In type 1 tumors, 11 of 16 were estrogen receptor-negative; in type 2 tumors, 2 of 16 were receptor-negative. Estrogen sulfotransferase levels in receptor-negative tumors were significantly lower than the levels in receptor-positive tumors (P = 0.025).