THE CLINICAL USE OF PENICILLIN

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Abstract
At this stage of development of penicillin therapy it is a matter of extreme delicacy to formulate statements which may be considered final with regard to the clinical use of penicillin. It is further true that the treatment of infections with penicillin is accompanied by many problems not as a rule encountered in the use of therapeutic agents heretofore available. It is well to recall that Fleming1 in 1929 found that the broth in which Penicillium notatum had grown was inhibitory for certain pathogenic organisms. He named the substance penicillin. Unfortunately, penicillin did not receive clinical application for a period of eleven years following his observations. Penicillin, however, was used in the laboratory during this time for the purpose of isolating unsusceptible organisms. It is proper to award to Fleming the prize of priority for the first attempt to use penicillin in human subjects. He used broth filtrates to

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