Novel Triterpene Sulfates from Fusarium compactum Using a Rhinovirus 3C Protease Inhibitor Screen.
- 1 January 1996
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 49 (6) , 541-546
- https://doi.org/10.7164/antibiotics.49.541
Abstract
Two novel triterpene sulfates have been isolated from Fusarium compactum by bioactivity-directed fractionation using an assay which measures the inhibition of proteolytic activity of rhinovirus 3C protease on a fluorogenic peptide substrate. The compounds were purified by countercurrent and reverse phase chromatographies. NMR, MS, UV and IR studies revealed two triterpene sulfates, uncommon metabolites of terrestrial fungi.Keywords
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