THE CALORIGENIC EFFICIENCY OF THYROID MATERIAL IN RELATION TO THYRQXINE AND TO IODINE CONTENT

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Abstract
The O2 consumption of normal and thyroidectomized rats was detd. in a closed circuit metabolic apparatus before and after treatment. Thyroid material was given by stomach tube on 3 consecutive days; change in metabolism observed on 5th day. The thyroidectomized rat was 25-30 times more sensitive than the normal. An increase of 25 to 30% in O2 consumption, most suitable for comparison, was obtained in operated rats by giving on each of these days 0.75 [gamma] thyroxine for each 10 g. body wt. Other substances on test were analyzed for thyroxine content by Leland-Foster method, and fed in proportionate doses. The following quantities of thyroxine, given in various compounds, produced a corresponding increase in metabolism: thyroid globulin, of 0.565% I and 025% thyroxine: 0.21-0.22 mg.; an acid-soluble hydrolysate, 0.262 I and 0.015% thyroxine: 0.45 mg.; U. S. P. thyroid powder, 0.2% I and 0.094% thyroxine: 0.3 mg.; thyroid powder of 0.465% I and 0.19% thyroxine: 0.25 mg. An acid-soluble hydrolysate of thyroid globulin, 4.24% I and 3.33 thyroxine gave inconsistent results. At 3 times the dosage the metabolism of the thyroidectomized rats approached that of the normal rats.

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