Failure of Naloxone to Influence Plasma Growth Hormone, Prolactin, and Cortisol Secretions Induced by Insulin Ilypoglycemia*
- 1 March 1980
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 50 (3) , 597-599
- https://doi.org/10.1210/jcem-50-3-597
Abstract
The effect of naloxone, a specific antagonist of opioid peptides, on plasma.GH, PRL, and cortisol responses to insulin-induced hypoglycerriia was studied in five healthy male subjects. The iv administration of regular insulin (0.15 U/kg) led to similar degrees of hypoglycemia on control and experimental days. Plasma GH, PRL, and cortisol levels rose significantly in response to insulin-induced hypoglycemia. A 2-h infusion of naloxone (0.8 mg/h) started 30 min before insulin injection did not alter either basal hormone levels or the hormone responses to insulin-induced hypoglycemia. These results suggest that endogenous opioid peptides do not play a major role in GH, PRL, or cortisol secretion induced by insulin hypoglycemia.Keywords
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