‘Hypercoagulable State’ in Children with Acute Leukemia or Disseminated Solid Tumors

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Abstract
Coagulation factors were assayed in 12 children with acute lymphoblastic leukemia and in 6 children with disseminated solid tumors. The large majority of these children showed evidence of ‘hypercoagulable state’, as manifested by shortened partial thromboplastin time and presence supernormal levels of fibrinogen and of factors VIII, IX, and XI. In children in whom factor VIII assays were done both at time of initial diagnosis and later when in complete remission, all cases showed a decrease in the factor VIII level, falling into the normal range. One child with persistent increase of factor VIII level showed early CNS relapse. Increased levels of factor VIII and other coagulation factors may often be sensitive parameters of leukemia or cancer activity.

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