Living Attenuated Measles-Virus Vaccine in Early Infancy

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Abstract
ENDERS and his associates1 2 3 4 have described the recovery of measles virus in human and animal-cell cultures and the propagation of the virus in hen's embryonated eggs and in cultures of chick embryo. Virus grown in tissue culture was characterized by marked attenuation of virulence for monkeys evidenced by failure to cause clinical illness, detectable viremia or recognizable changes in the central nervous system. Such attenuated virus induced only mild clinical illness in children inoculated subcutaneously. Neutralizing and complement-fixing antibodies against measles developed in the recipients in titers comparable to those in patients convalescing from natural measles.In a previous study . . .

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