The effect of 5-hydroxytryptophan on food intake and on the anorexic action of amphetamine and fenfluramine
- 1 January 1975
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 27 (1) , 31-37
- https://doi.org/10.1111/j.2042-7158.1975.tb09374.x
Abstract
5-Hydroxytryptophan (5-HTP), amphetamine and fenfluramine suppressed food intake in normal rats and in animals with lesions of the lateral hypothalamus. The anorexic effect of amphetamine was reduced in lesioned animals compared with controls while the effect of 5-HTP like that of fenfluramine was increased. When administered in conjunction with the anorexic drugs, 5-HTP markedly potentiated the anorexic effect of amphetamine in both control and lesioned animals. However, 5-HTP potentiated fenfluramine anorexia only in lesioned rats. These findings provide further evidence for the role of 5-hydroxytryptamine (5-HT), in the anorexic effect of fenfluramine, and suggest that a 5-HT mechanism, inhibitory for feeding, produces particularly severe suppression of food intake in rats with lateral hypothalamic lesions.Keywords
This publication has 27 references indexed in Scilit:
- Interactive effect of (±)-fenfluramine and (+)-amphetamine on feeding in ratsJournal of Pharmacy and Pharmacology, 1974
- AnnouncementsNature, 1973
- Overeating and Obesity from Damage to a Noradrenergic System in the BrainScience, 1973
- Sleep-waking patterns in cats after administration of fenfluramine and other monoaminergic modulating drugsPharmacology Biochemistry and Behavior, 1973
- Chemically induced degeneration of indoleamine-containing nerve terminals in rat brainBrain Research, 1972
- Some 5-hydroxytryptamine-like actions of fenfluramine: a comparison with (+)-amphetamine and diethylpropionJournal of Pharmacy and Pharmacology, 1971
- Is 5-hydroxytryptamine involved in the mechanism of action of fenfluramine?Journal of Pharmacy and Pharmacology, 1971
- Norepinephrine: Reversal of Anorexia in Rats with Lateral Hypothalamic DamageScience, 1971
- Antagonism by methysergide of the 5-hydroxytryptamine-like action of toxic doses of fenfluramine in dogsJournal of Pharmacy and Pharmacology, 1970
- Medial forebrain bundle and “feeding centers” of the hypothalamusJournal of Comparative Neurology, 1961