Preparation and evaluation of 3,4"-ester derivatives of 16-membered macrolide antibiotics related to tylosin.
- 1 January 1986
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 39 (12) , 1724-1735
- https://doi.org/10.7164/antibiotics.39.1724
Abstract
A large group of ester derivatives of tylosin-related macrolide was prepared in which the hydroxy groups at C-3 and C-4" were acylated by either chemical or biochemical methods. Most of the derivatives exhibited excellent in vitro antimicrobial activity. However, only the 3,4"-diacyl derivatives of tylosin and macrocin showed any significant im parameters of in vivo efficiency against experimental infections in rodents.This publication has 0 references indexed in Scilit: