Raised plasma levels of thromboxane B2in systemic mastocytosis

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Abstract
Plasma levels of thromboxane (TX) B2 and 6-keto-prostaglandin (PG) F1.alpha. were measured in 6 patients with systemic mastocytosis. Patients with systemic mastocytosis had significantly higher plasma TXB2 levels (530 .+-. 105 pg/ml, mean .+-. SEM [standard error of the mean]) than controls (118 .+-. 8.2 pg/ml, P < 0.001) and significantly lower 6-keto-PGF1.alpha. levels (40 .+-. 3.1 pg/ml, mean .+-. SEM) than controls (49 .+-. 1.6 pg/ml, P < 0.05). The mechanism of the raised plasma TXB2 levels is not clear. One possible explanation is that the high TX levels are secondary to an increased production of leukotrienes C and D, which are constituents of slow reacting substances of anaphylaxis.

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