Correction of prior estimate of the biological activity of an N-trifluoroacetyl analog of D-threo-chloramphenicol relative to chloramphenicol

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Abstract
The inhibitory rate constants, k, for the inhibition of the rate of Escherichia coli generation at various concentrations, C, of chloramphenicol and its N-trifluoroacetyl analogue were determined in vitro in accordance with kapp = k0-kC where kapp is the apparent first-order generation rate constant at a drug concentration C and k0 is that constant in the absence of drug. The activity of the analogue was 1/10 that of chloramphenicol in contrast to a previously reported value.

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