Numerical chromosome variation in mouse spermatogonla resulting from alcohol consumption

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Abstract
Male mice were force fed ethyl alcohol in tragastrically at increasing daily doses. The animals were killed at various times after the initiation of alcohol Ingestion. Chromosome numbers per cell were counted from spermatogonial mitoses and compared with those from controls that were not exposed to alcohol. An average of 16 percent of the spermatogonial mitoses from alcohol ingesting animals had hypodiploid numbers (usually 2n-1) compared to 6 percent In the control an irnals. No correlation between the total amount of alcohol consumed and the number of hypodtploid sparmatogonia was noted.

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