4-Leucine-Oxytocin: Natriuretic, Diuretic, and Antivasopressin Polypeptide
- 19 July 1968
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 161 (3838) , 280-281
- https://doi.org/10.1126/science.161.3838.280
Abstract
During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucine-oxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to freewater clearance.Keywords
This publication has 5 references indexed in Scilit:
- STUDIES ON THE RENAL ACTIVITY OF OXYTOCINThe Lancet Healthy Longevity, 1966
- Effects of Neurohypophysial Hormones and Their Deamino Analogues on Renal Excretion of Na, K and Water in RatsEndocrinology, 1965
- Inhibition of Vasopressin Antidiuresis by Extracts of Pituitaries from Rats with Hereditary Hypothalamic Diabetes Insipidus and by OxytocinEndocrinology, 1965
- Effect of oxytocin structural changes on rat renal excretion of Na, K, and waterAmerican Journal of Physiology-Legacy Content, 1962
- Posterior Pituitary Extracts and Excretion of Electrolytes by the RatAmerican Journal of Physiology-Legacy Content, 1952