Pro-drugs for the oral delivery of disodium cromoglycate.

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Abstract
Bifunctional pro-drugs of disodium cromoglycate (DSCG), incorporating both lipophilic and hydrophilic pro-moieties, were designed to improve the oral absorption of DSCG, an antiallergic agent used clinically. The synthesized pro-drugs were found to possess the desired properties for an orally active pro-drug. Among the pro-drugs tested, KY-556 (carrying twin ethyl pro-moieties and an L-lysyl pro-moiety) was particularly well absorbed orally and, as expected, displayed good antiallergic activity in the rat passive cutaneous anaphylaxis test.

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