1,25-DIHYDROXYCHOLECALCIFEROL IN HYPOPHOSPHATAEMIC OSTEOMALACIA PRESENTING IN ADULTS

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Abstract
The effects of exogenous 1,25-dihydroxycholecalciferol (1,25(OH)2D3) in 2 adults with late-onset hypophosphatemic osteomalacia were studied. In the presence of elevated 25-hydroxyvitamin D levels 1,25(OH)2D3 improved intestinal 47Ca absorption and increased urinary Ca, phosphate and hydroxyproline excretion. Hypophosphatemia, parathyroid hormone and bone mineralization were not significantly affected. The rise of the 1,25-dihydroxyvitamin D concentrations was dose dependent. The impaired renal phosphate conservation, the primary defect in this disorder, is not corrected by exogenous 1,25-dihydroxycholecalciferol.

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