THE ABROGATION OF SHEEP ERYTHROCYTE TOLERANCE IN RATS BY MEANS OF THE TRANSFER OF ALLOGENEIC LYMPHOCYTES
Open Access
- 1 November 1970
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 132 (5) , 916-925
- https://doi.org/10.1084/jem.132.5.916
Abstract
Whereas the transfer of lymphocytes from normal syngeneic donors fails to abrogate tolerance of sheep erythrocytes in rats, lymphocytes from allogeneic donors are effective. When tolerance is abrogated in this situation, the hemolysin-forming cells are predominantly of host origin. Immunological interaction between transfused lymphocytes and host cells is a prerequisite for the abrogation of tolerance. From the time required for abrogation to occur after transfer of the allogeneic cells, it is suggested that tolerance of sheep erythrocytes in rats represents the repression of a specific reactivity in cells rather than the elimination or irreversible inactivation of reactive cells. This explanation implies the existence of specifically tolerant cells.Keywords
This publication has 5 references indexed in Scilit:
- THE IMMUNOLOGICAL CAPACITY OF LYMPHOCYTES FROM NORMAL DONORS AFTER THEIR TRANSFER TO RATS TOLERANT OF SHEEP ERYTHROCYTESImmunology & Cell Biology, 1970
- THE TRANSFER OF IMMUNOLOGICAL COMPETENCE TO RATS TOLERANT OF SHEEP ERYTHROCYTES WITH LYMPHOCYTES FROM NORMAL RATSImmunology & Cell Biology, 1970
- The Origin of Antibody Forming Cells from LymphocytesPublished by S. Karger AG ,1968
- CELL TO CELL INTERACTION IN THE IMMUNE RESPONSEThe Journal of Experimental Medicine, 1968
- FURTHER IMPROVEMENTS IN PLAQUE TECHNIQUE FOR DETECTING SINGLE ANTIBODY-FORMING CELLS1968