The induction of ω and β-oxidation of fatty acids and effect on α2uglobulin content in the liver and kidney of rats administered 2, 2, 4-trimethylpentane
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 17 (4) , 513-522
- https://doi.org/10.3109/00498258709043958
Abstract
1. The effect of daily administration of 12 mmol/kg 2, 2, 4-trimethylpentane for 10 d on hepatic and renal microsomal mono-oxygenase activity, peroxisomal β-oxidation and the concentration of α2u-globulin has been examined in male and female rats. 2. 2, 2, 4-Trimethylpentane produces liver and, to a lesser extent, kidney enlargement. This is associated with the selective induction of cytochrome P-450-mediated ω-oxidation and peroxisomal β-oxidation of fatty acids and proliferation of peroxisomes. Male rats show a more marked response than female rats. 3. 2, 2, 4-Trimethylpentane produces an increase in α2u-globulin in the kidney of male rats. 4. The relevance of selective induction of ω- and β-oxidation of fatty acids and accumulation of α2u-globulin to renal tubular necrosis in male rats requires further study.This publication has 36 references indexed in Scilit:
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