Hyperpigmentation associated with oral minocycline

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Abstract
Two patients receiving minocycline [an antibiotic] developed blue-black pigmentation on the legs. Biopsies from the pigmented areas demonstrated granules containing Fe, a pigment with staining properties similar to melanin, and a 3rd pigment which may be a degradation product of minocycline. EM showed that some, but not all, of the granules were membrane-bound and situated mainly within macrophages. Analytical EM showed that the granules contained Fe, S, Cl and in 1 case Ca.

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