Manganese Superoxide Dismutase Alanine-to-Valine Polymorphism at Codon 16 and Lung Cancer Risk
Open Access
- 5 December 2001
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 93 (23) , 1818-1821
- https://doi.org/10.1093/jnci/93.23.1818
Abstract
Manganese superoxide dismutase (MnSOD) catalyzes the dismutation of a specific type of reactive oxygen species, superoxide radicals, into hydrogen peroxide and oxygen (1). Accumulation of reactive oxygen species can damage DNA, proteins, and lipids, leading to the initiation or promotion of cancer (2,3). MnSOD, the only known superoxide scavenger in mitochondria, may be particularly important for antioxidant defense because mitochondria are the major sites for cellular metabolism and hence production of reactive oxygen species (4).Keywords
This publication has 23 references indexed in Scilit:
- Influence of polymorphism in the manganese superoxide dismutase locus on disease outcome in rheumatoid arthritis: Evidence for interaction with glutathione S-transferase genesArthritis & Rheumatism, 2000
- Oxyradicals and DNA damageCarcinogenesis: Integrative Cancer Research, 2000
- Polymorphisms in the SOD2 and HLA-DRB1 Genes Are Associated with Nonfamilial Idiopathic Dilated Cardiomyopathy in JapaneseBiochemical and Biophysical Research Communications, 1999
- Decreased Expression of Manganese Superoxide Dismutase in Transformed Cells Is Associated with Increased Cytosine Methylation of the SOD2 GeneDNA and Cell Biology, 1999
- Analysis of Mitochondrial Targeting Sequence and Coding Region Polymorphisms of the Manganese Superoxide Dismutase Gene in German Parkinson Disease PatientsBiochemical and Biophysical Research Communications, 1999
- Superoxide in ApoptosisJournal of Biological Chemistry, 1998
- Transfection and Expression of MnSOD cDNA Decreases Tumor Malignancy of Human Oral Squamous Carcinoma SCC-25 CellsHuman Gene Therapy, 1997
- Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutaseOncogene, 1997
- Free radicals, antioxidant enzymes, and carcinogenesisFree Radical Biology & Medicine, 1990
- Manganese superoxide dismutase in normal and transformed human embryonic lung fibroblastsFree Radical Biology & Medicine, 1989