PRETRANSPLANT HERPESVIRUS SEROLOGY AND ACUTE GRAFT-VERSUS-HOST DISEASE

Publisher Website
Google Scholar
Abstract
Logistic regression was used to analyze the influence of pretransplant herpesvirus antibodies, in both patients and donors, on the development of acute graft-versus-host disease in 111 consecutive HLA-identical bone marrow recipients. In bivariate analysis, recipient seropositivity for cytomegalovirus (P = 0.01), donor seropositivity for herpes simplex virus (P = 0.02), and low bone marrow cell dosage (PP values were PP = 0.07 for a positive donor HSV serology. Positive serology for 1–2 herpes-viruses among recipients or donors both resulted in a 12% incidence of grade II–IV acute GVHD. Positive serology for 3–4 herpesviruses among patients or donors resulted in an incidence of 32% and 38% of acute GVHD, respectively (P<0,05). It is concluded that recipient and donor pretransplant herpesvirus immunity can be used to calculate the risk of moderate-to-severe acute GVHD.