A clinical pharmacological comparison of diclofensine (Ro 8‐4650) with nomifensine and amitriptyline in normal human volunteers.

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Abstract
Healthy male volunteers (10) participated in a double-blind placeblo-controlled crossover comparison of the pharmacodynamic profiles of single oral doses of diclofensine 25 and 50 mg, nomifensine 75 mg and amitriptyline 50 mg [antidepressants]. Diclofensine did not influence salivary flow or consistently affect pupil diameter and had no significant effect on subjective measurements of sedation and mood. It had no effect on reaction time, or on critical flicker frequency. Amitryptyline significantly reduced salivary flow, produced significant sedation and impairment of mood, prolonged reaction time, and appeared to decrease (but not significantly) critical flicker frequency. Nomifensine significantly reduced (i.e., improved) reaction time, and inhibited salivary flow. Diclofensine did not significantly influence heart rate, blood pressure, systolic time intervals or high speed ECG. No significant treatment-related differences were observed in serum prolactin, cortisol or growth hormone levels.